Neal Lab @ UC San Diego

Exploring the multi-faceted roles of rhomboids in protein homeostasis

We are interested in understanding protein quality control pathways, with a particular emphasis on pathways that detect and destroy toxic misfolded proteins. An understanding of these pathways allows us to define the mechanisms that protect the organismal proteome in health and disease, and eventually devise methods to harness cellular quality control to modify the proteome in the laboratory and the clinic. We take advantage of the laboratory’s unique set of skills in genetics, biochemistry, functional genomics, and cell biology to extend these lines of inquiry and to train the next generation of scientific leaders!